- J Korean Neurol Assoc. 2003;21(2):163-168.
- EEG Coherence in Alzheimer s Disease
- Yong Tae Kwak
- "Department of Neurology, Hyoja Geriatric Hospital Department of Neurology, Sanggye Paik Hospital, Inje University College of Medicine"
- 알쯔하이머병에서 뇌파 C o h e r e n c e
- 곽용태 , 함동석 한일우 백종삼
- 효자병원 신경과,인제대학교 의과대학 상계백병원 신경과학교실
- Abstract
- "Background : EEG coherence can be used to evaluate the functional cortical connections and to get information
about the synchronization of the regional cortical activity. We studied EEG coherence in patients affected by clinically
probable Alzheimer s disease (AD) in order to quantify the modifications in the cortico-cortical or cortico-subcortical
connections. Methods : The EEGs were recorded in 62 AD patients and in 30 normal age-matched subjects from 16
electrodes with linked-ears reference. Spectral parameters and coherence were calculated by a multichannel autoregres-sive
model using 20 artifact-free 2-sec epoch in normal controls and AD patients. Results : In AD patients, alpha coher-ence
in frontal field and theta, alpha interhemispheric coherence was significantly decreased, whereas alpha, beta coher-ence
in posterior field was significantly increased. Some electrodes in the anterior field showed significant negative cor-relation
with MMSE, whereas other electrodes in the posterior field showed significant positive correlation with
MMSE. Conclusions : This study suggests that coherence is a useful tool for understanding electrophysiologic change
of AD and for correlating with the severity of cognitive dysfunction. And these coherence changes can be interpreted as
the effects of neuronal loss and neocortical disconnection.Key Words : EEG, Coherence, Alzheimer s disease"
Keywords :