- J Korean Neurol Assoc. 2003;21(1):54-61.
- "Volume Changes of Frontal Lobe and Hippocampus in Juvenile Myoclonic Epilepsy"
- Woo Suk Tae
- "Neuroimaging Laboratory* of Neurology, Department of Neurology ,Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea"
- "청소년기 근간대성간질 환자의 전두엽과 해마 부피의 변화"
- 태우석 , 이은경 주은연 서대원 홍승봉
- 성균관대학교 의과대학 삼성서울병원 신경영상연구실, 신경과
- Abstract
- "Background : In order to investigate the structural abnormalities in juvenile myoclonic epilepsy (JME), the volumes
of the hippocampus and frontal lobe were measured. Methods : Nineteen JME patients and 19 age- and sex-matched
normal controls underwent a 1.6 mm thick brain SPGR MRI. The volumes of the frontal lobe and hippocampus were
measured with a volume of interest method. The differences of volumes between JME and normal groups were com-pared.
The volumes were also compared between the early and late onset groups, and between the short and long
seizure duration groups. The correlations between the volumes of the frontal lobe, hippocampus, or mid-sagittal area of
the corpus callosum, and the age of seizure onset or the duration of disease were tested. Results : The cerebral volume
was not found to be different between the JME and normal groups (p=0.521). The left hippocampus was significantly
smaller in the JME group (p=0.032) while the left frontal lobe was significantly larger in the JME group (p=0.004). The
area of the rostral body of corpus callosum showed a significant positive correlation with the age of onset (r=0.561,
p=0.012). The right frontal lobe volume showed a significant negative correlation with the duration of disease (r=-0.511,
p=0.025). Conclusions : These results imply that JME has volume changes in the frontal lobe and hippocampus.
The volume reduction of the right frontal lobe in patients with a longer disease duration may suggest a progressive
nature of JME. The smaller rostral body of the corpus callosum in patients with earlier seizure onset may suggest an
ontogenic abnormality of JME.Key Words : Juvenile myclonic epilepsy, MRI, Frontal lobe, Hippocampus, Volumetry"
Keywords :