- J Korean Neurol Assoc. 2003;21(1):27-31.
- "Correlation between Multifocal Hypointense Cerebral Lesions on Gradient-echo MRI and White Matter Changes in Patients with Stroke"
- Jin-Kook Park
- Department of Neurology, College of Medicine, The Catholic University of Korea
- 뇌졸중 환자의 경사에코 자기공명영상에서 관찰되는 다병소 저신호 강도 병변과 백질 변화의 관련성
- 박진국 , 최영빈 이승재 양동원 정성우 김범생
- 가톨릭대학교 의과대학 신경과학교실
- Abstract
- "Background : The multifocal hypointense cerebral lesions (MHCLs) on gradient echo (GE)-MRI and white matter
changes on T2WI have been thought to be indicative of microangiopathy. The purpose of this study is to elucidate the
relationship between MHCLs and white matter (WM) changes and the clinical significance of WM changes in stroke
patients. Methods : We retrospectively reviewed MRI and clinical data of 115 patients with stroke (56 female and 59
male). Periventricular and deep white matter hyperintensity (PVHI and DWMHI) were measured by semiquantative rat-ing
scale proposed by M?ntyla. The round, hypointense signal, less than 7 mm in diameter on GE-MRI were counted as
MHCLs. The association between risk factors of stroke and MHCLs on GE-MRI and sum of the white matter change
scores and total number of MHCLs were analyzed, respectively. Results : MHCLs on GE-MRI were significantly asso -ciated
with old age (p<0.05) and hypertension (p<0.001) among risk factors of stroke. The distribution of MHCLs in
subcortical area is associated with hypertension (p<0.05) and total number of MHCLs was significantly associated with
sum of the white matter change scores (p<0.05). Conclusions : MHCLs on GE-MRI were significantly associated with
severity of WM changes. Severe WM change may be an indicator of advanced small artery disease of the brain with an
increased risk factor for bleeding. This should be taken into consideration when treating patients with stroke.Key Words : Multifocal hypointense cerebral lesions, Hypertension, Gradient echo-MRI, White matter changes"
Keywords :