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J Korean Neurol Assoc. 2002;20(6):624-629.
- "Differentiation of Alzheimer s Disease from Vascular Dementia Using the
Modified Mini- Mental State Examination"
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Ae-Young Lee, M.D.
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"Department of Neurology, College of Medicine, Chungnam National University,
Section of Neuropsychology, Chungnam National University Hospital"
- "Modified Minimental Status (3MS)검사를 이용한
알쯔하이머병과 혈관성치매의 감별"
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이애영, 손은희 박현주
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충남대학교 의과대학 신경과학교실,충남대학교병원 신경심리검사실
- Abstract
- "Background : Alzheimer s disease (AD) and vascular dementia (VaD) are the most frequently occurring dementia.
Although accurate differentiation of dementia subtype is important in treatment perspective, it is not easy even using
expensive and time-consuming devices. To evaluate diagnostic value of the Modified Mini-Mental State (3MS) exami-nation
as a dementia screening and whether the first recall (FR) and delayed recall(DR) of 3MS are helpful in differenti-ating
AD from VaD. Methods : Patients comprised of 64 cases diagnosed for dementia at the Neurology department.
Diagnosis of probable AD (n=34) and VaD (n=30) were made according to consensus criteria. Cognitive status was
measured by the Mini-Mental State Examination (MMSE) and 3MS. Receiver operating characteristic (ROC) curves
were used to identify the optimal FR and DR for differentiating AD from VaD. Ninety-three age- and education-matched
controls were evaluated. The neuropsychologist was blind to clinical diagnosis. Results : Sensitivity (SN),
specificity (SP), diagnostic accuracy (DA), and positive likelihood ratio (+LR) of 3MS (cutoff score=76) were 0.75,
0.68, 0.70 and 2.34. The optimal score of FR and DR to differentiate AD from VaD were 2 (SN=0.81, SP=0.76, &
+LR=3.38) and 1 (SN=0.81, SP=0.71, & +LR=2.79), respectively. Conclusions : The diagnostic value of 3MS is com-parable
to that of MMSE as well as covers broader cognitive functions and has wider difficulty levels. Among dementia
patients, a low FR and DR scores on the 3MS produce small to moderate increases the post-test probability of AD.Key Words : Alzheimer s disease, Vascular dementia, 3MS"
Keywords :
- 초록
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