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J Korean Neurol Assoc. 2002;20(4):385-393.
- "Genomic Changes in the Striatum
of Unilateral 6-hydroxydopamine Lesioned Parkinson Rat Model"
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Byung Jo Kim
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Department of Neurology and Anatomy, Korea University School of Medicine
- 6 -HydroxydopamIne 을 이용한 편측 파킨슨 흰쥐 모델에서 선조체의 유전체 변화
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김병조, 박건우 김 현 이대희
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고려대학교 의과대학 신경과학교실, 해부학교실
- Abstract
- "Background : Parkinson ’s disease is the primary degenerative disease characterized by rigidity, bradykinesia and
resting tremor. Even though dopaminergic cell loss of the substantia nigra compacta is a main pathogenesis of the
Parkinson ’s disease, the striatal dysfuntion is major pathophysiology of pakinsonian symptoms. Methods : Since gene
expression profile can explain the symptomatic varieties of Parkinson ’s disease, gene expression was investigated in
the striatum of rat brain after lesioning of unilateral substantia nigra compacta with 6-hydroxydopamine using cDNA
microarray technique for the first time. The expression patterns of 5,200 rat brain cDNAs were screened and clustered
according to the function of gene. The expression patterns of enkephaline and substance-P mRNA were also studied for
validation of animal preparation. Results : Various genes involved in apoptosis, cytokines. Cytoskeletal molecules, neu-rotrophic
factors, receptors, intracellular Ca
2+
metabolism, signal transduction, stress protein, cell cycle regulator pro-tein,
and expressed sequence tags(EST) have shown significant expression changes. Conclusions : These gene expres-sions
provide the global assessment of the processes involved in secondary change of striatum afforded by dopaminer-gic
denervation at molecular levels.Key Words : Parkinson ’s disease, Microarray, 6-hydroxydopamine, Striatum"
Keywords :
- 초록
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