- J Korean Neurol Assoc. 2002;20(3):260-264.
- "Interictal Motor Cortex Excitability in Migraine and Chronic Tension Type Headache using Transcranial Magnetic Stimulation"
- Eun-Hyang Song, M. D.
- "Department of Neurology, Seoul Veterans Hospital Department of Neurology, Anyang Hospital"
- "경두개 자기자극을 이용한 편두통 및 만성 긴장성 두통에서의 발작간 운동피질 흥분성"
- 송은향 , 이정석 최용석 김정미 김두응 한정호
- 서울보훈병원 신경과, 안양병원 신경과
- Abstract
- "Background : The pathophysiology of migraine is only partly understood. Transcranial magnetic stimulation has
been developed to study cortical physiology noninvasively. Chronic tension-type headache has not been studied with
transcranial magnetic stimulation. Among other hypotheses, it has been proposed that interictal hypoexcitability could
be partly responsible for the migraine. M e t h o d s : Patients were divided into three groups: normal subjects(n=30),
migraine with(n=11) or without aura(n=19) and chronic tension-type headache(n=30) according to the International
Headache Society criteria. We studied cortical excitability between normal subjects and patients with migraine with or
without aura and between normal and patients with chronic tension-type headache. Results : The mean amplitude of
cortex and spinal cord for normal subjects was 3.76 ±1.74 mV, 2.03 ±1.54 mV(abductor digiti minimi muscles, respec-tively)
and 2.99 ±2.04 mV, 3.88 ±3.89 mV(abductor hallucis muscles, respectively). The mean amplitude of cortex and
spinal cord for migraine with aura or without aura was 2.16 ±1.21 mV, 0.90+0.80 mV(abductor digiti minimi muscles,
respectively) and 1.88 ±1.23 mV, 2.31 ±2.25 mV(abductor hallucis muscles, respectively). The mean amplitude of cor-tex
and spinal cord for chronic tension-type headache was 1.61 ±0.50 mV, 0.72 ±0.32 mV(abductor digiti minimi mus-cles,
respectively) and 1.54 ±0.55 mV, 1.51 ±0.59 mV(abductor hallucis muscles, respectively). The amplitude of motor
evoked potentials of cortex and spinal cord in migraine and chronic tension-type headache showed significant decreases
compared to normal subjects(p<0.001). Conclusions : These results are explained by cortical and spinal hypoexcitabili-ty
in migraine and chronic tension-type headache. We suggest that enhanced serotonergic activity could be some rule
for cortical hypoexcitability.Key Words : Transcranial magnetic stimulation, Interictal cortical excitability, Headache"
Keywords :