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J Korean Neurol Assoc. 2002;20(3):234-242.
- "The Effect of Subthalamic Nucleus Stimulation
in Patients with Advanced Idiopathic Parkinson■s Disease"
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Won Chan Kim, M.D.
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"Department of Neurology, Yongdong Severance Hospital
Department of Neurosurgery, Severance Hospital, Yonsei University College of Medicine"
- "진행된 특발성 파킨슨병에서
시상하핵 자극의 효과"
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김원찬 , 오승헌 김현숙 류철형찬 이진구 장진우 이명식
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연세대학교 의과대학 영동세브란스병원 신경과,세브란스병원 신경외과학교실
- Abstract
- "Background: To determine the efficacy and safety of subthalamic nucleus (STN) stimulation in patients with
advanced Parkinson s disease (PD). Methods : In 5 patients with PD, we evaluated the effect of bilateral STN stimula-tion.
Using the Unified PD Rating Scale (UPDRS), Clinical Dyskinesia Rating Scale, Activities of Daily Living(ADL)
Score and patient s diary, we evaluated the patients before and at one, three and 12 months after surgery. We examined
the patients while they were drug off and on . Results : While patients were off , stimulation induced a signifi-cant
reduction in the UPDRS part III score by 46% at 12 months after the operation, compared to the baseline state.
During drug on state, levodopa-induced dyskinesias were reduced by 88% at 12 months after the operation. Off-peri-od
dystonia was reduced by 45% at 12 months after the operation. ADL scores also improved after the stimulation.
Patients diaries showed significant reduction in the off period while awake (73% reduction at 12 months). The daily
dose of levodopa was reduced by 56% at 12 months after the operation. There was no significant complication related
to the surgical procedure or electrical stimulation. Conclusions : We conclude that STN stimulation is an effective and
safe treatment strategy for the patients with advanced PD.Key Words : Idiopathic Parkinson s disease, Subthalamic nucleus, Stimulation"
Keywords :
- 초록
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