- J Korean Neurol Assoc. 2002;20(2):153-163.
- "Hippocampus/Frontal Gyrus FLAIR Signal Intensity Ratio in Patients with Mesial Temporal Lobe Epilepsy"
- Young-Min Shon
- "Department of Neurology, College of Medicine, The Catholic University of Korea, Department of Neurology, Neuroimage Laboratory, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea"
- 내측두엽간질 환자의 해마/전두엽 FLAIR 신호강도 비율
- 손영민 , 홍승봉 이은경 태우석 서대원 신원철
- 가톨릭대학교 의과대학 신경과학교실, 성균관대학교 의과대학 삼성서울병원 신경과학교실, 신경영상연구소
- Abstract
- "Background : The typical MRI features of hippocampal sclerosis (HS) are volume loss and increased T2 weighted
signal intensity. Hippocampal volumetry and T2 relaxometry are useful quantitative methods for presurgical diagnosis
of HS, especially in the cases of mild, bilateral or focal hippocampal atrophies. We investigated the value of a new
quantitative method using FLAIR (Fluid Attenuated Inversion Recovery) MR images compared to those of visual interpretation
and MR volumetry. Methods : Forty-five patients with mesial temporal lobe epilepsy (TLE) and 21 underwent
volumetric MRI (T1-weighted, SPGR, T2 weighted, and FLAIR images). All patients underwent anterior temporal
lobectomy with amygdalohippocampectomy., where visual analysis and hippocampal volumetry were performed. The
absolute and normalized values of hippocampal FLAIR signal intensity [hippocampal FLAIR intensity/superior frontal
FLAIR intensity=Hippocampal-Frontal Signal Intensity Ratio (HFSR)] were obtained from both normal subjects and
patients with TLE. Results : The pathology of resected hippocampus showed HS in all patients. Visual interpretation of
presurgical MRI failed to lateralize HS in 10 patients (22.2%). Among these 10 patients, the HS was lateralized by
HFSR method in seven patients (70%) [Five (50%) by right-to-left difference of HFSR and the other two (20%) by
analysis of a longitudinal regional curve of HFSR] while it was further lateralized by hippocampal volumetry in only
three. Conclusions : In presurgical evaluation of patients with TLE, the hippocampal FLAIR signal analysis appeared
to be complementary to visual interpretation and MR volumetry.Key Words : Temporal lobe epilepsy, Volumetry, FLAIR signal ratio, Hippocampal sclerosis"
Keywords :