- J Korean Neurol Assoc. 2002;20(2):101-109.
- Epileptogenesis
- Jae-Moon Kim
- "Department of Neurology, Chungnam National University Hospital, Brain Research Institute, Chungnam National University"
- 경련의 발생기전
- 김재문 ,
- 충남대학교병원 의과대학 신경과학교실
- Abstract
- "Epilepsy is a disease characterized by paroxysmal, hypersynchronous, and excessive electrical discharges . Despite
long and extensive research on epileptogenesis, clear explanation of the basic mechanisms of epilepsy has yet to be
established. Considering the diverse etiologies of epilepsy and experimental seizure models, a seizure has many mechanisms
affecting single neurons and its neural circuits. Epileptic neuron has the ability of spontaneous depolarization and
firing. To achieve depolarization, these neurons tend to have increased membrane excitability by interaction of neurotransmitter
receptors and ion channels and synapses, but excitable single neuron does not necessarily mean hyperexcitable
neural circuit. Synchrony, burst, and neural interactions are required for the spreading of the electrical discharges.
Increased membrane excitability is mainly achieved by increased influx of calcium and decreased potassium
and chloride transport mechanism. With this membrane excitability, paroxysmal depolarization shift (PDS) needs
synaptic excitation represented by giant EPSP. Synaptic function is mainly controlled by neurotransmitters such as
GABA and glutamate. The imbalance of these important neurotransmitters has a crucial role in epilepsy. Synaptic reorganization
and associated change of neurotransmitter plays an essential role in chronic epileptogenesis key words : Epilepatogenesis, Newrotromsmitter, Ion channel, Synaptic reorganizotion"
Keywords :