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J Korean Neurol Assoc. 2002;20(1):34-42.
- Sexual Dimorphism of Human Corpus Callosum Using Quantitative MRI
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Woo Suk Tae
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"Neuroimaging Laboratory of Neurology, Department of Neurology
Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea"
- "정량적 자기공명영상을 이용한 성별에 따른
뇌량의 동종이형성(同種二形性) 연구"
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태우석, 홍승봉
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성균관대학교 의과대학 삼성서울병원 신경영상연구실 신경과
- Abstract
- "Background : To investigate the sexual dimorphism in human corpus callosum (CC), we measured the mid-sagittal
area of corpus callosum and its seven sub-regions. Methods : Eighteen men (23.0 9.1 years) and 16 women (27.3 11.3
years) underwent 1.6 mm thickness SPGR (spoiled gradient recalled in the steady state) MRI. All subjects are right
handed and had no neurological or psychiatric diseases. The education level was controlled. Exact mid-sagittal image
was obtained by image reconstruction and geometric correction. According to the Witelson s criteria, CC was divided
into seven subregions (a1~a7 from anterior to posterior) and then normalized by mid-sagittal cerebral area (b1~b7),
cerebral volume (c1~c7) and whole CC (d1~d7). In each subregion, the pixel number was counted. The difference of
CC areas between men and women were tested by t-test and ANCOVA. R e s u l t s : The volume of the cerebrum
(p<0.001) and the mid-sagittal cerebral area (p=0.002) were significantly larger in men by t-test. B2 (normalized genu
by mid-sagittal cerebral area, p=0.040), c2 (normalized genu by cerebral volume, p=0.015), cT (normalized whole CC
by cerebral volume, p=0.023) were significantly larger in women. cT excluding c2 was not significantly different
(p=0.065). But, there was no significant difference in a1~a7, aT with ANCOVA (adjusted by age and cerebral volume).
A2 (r=0.493), b2 (r=0.655), b5 (r=0.591), b7 (r=0.526), bT (r=0.611), c2 (r=0.548), c5(y=0.522) and cT (r=0.495) had
significantly higher correlation with age (all p<0.05) in men. However, they had no significant correlation with age in
women. C o n c l u s i o n s : In this preliminary study, we hypothesize the genu of CC is larger in women than in men.
However, with age, men s CC has evolving growth pattern whereas women s CC remains relatively static.
Key Words : Corpus callosum, Sexual dimorphism, Magnetic resonance imaging"
Keywords :
- 초록
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