-
-
J Korean Neurol Assoc. 2002;20(1):1-7.
- Pathophysiology of Pain
-
Jun Kim
-
"Department of Physiology and Biophysics, Seoul National University College of Medicine,
Department of Physiology, Dankook University College of Medicine"
- 통증의 병태생리
-
김전 , 정승준
-
서울대학교 의과대학 생리학교실, 단국대학교 의과대학 생리학교실*
- Abstract
- "Pain is a sensation induced by activation of the peripheral nociceptors when tissue is damaged by direct stimuli or has
a possibility of damage. There exist nociceptors for detecting the noxious stimuli in periphery, and the nociceptive
informations were transmitted via Aδ- or C-fibers. Acute pain is caused by direct noxious stimuli, and chronic pains are
produced by inflammation or nerve damage. The mechanisms of chronic pains are associated with the changes of central
nervous system (CNS) as well as those in peripheral nocicpetors. Immune cells and neurotrophins are also involved
in the mechanisms of chronic pain. Recently, there has been a tendency among pain researchers that chronic pain might
be explained the plastic changes in the nociceptive synaptic transmission through the spinal cord. These are associated
with changes in intracellular Ca2+ concentration, subsequent intracellular signal transduction pathways, which result in
changes in AMPA receptor dynamics. This sequential changes may induce allodynia and hyperalgesia observed in
chronic pain patients. This review suggests new interpretation for pain mechanism and new approach for chronic pain.Key Words : Pain, Chronic Pain, Plasticity, Nociceptor"
Keywords :
- 초록
-
