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J Korean Neurol Assoc. 2001;19(3):239-244.
- A Neuronal Hyper-responsiveness in PRVEPs of Migraine Patients
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Woo Jung Kim, M.D., Jeong Ho Han, M.D., Hyun Wook Ha, M.D., Eun Hyang Song, M.D., Jung Suk Lee, M.D., Doo Eung Kim, M.D.
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Department of Neurology, Korea Veterans Hospital
- 편두통 환자의 형태변환성 시각유발전위에서의 신경원성 과반응
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김우정, 한정호 하현욱 송은향 이정석 김두응
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한국보훈병원 신경과
- Abstract
- "Background : Although a number of visual evoked potentials (VEPs) studies have been performed to elucidate the pathophysiology of migraines, their results have been controversial. We studied the pattern-reversal visual evoked poten-tials (PRVEPs) during long periods of stimulation to show whether or not PRVEPs in migraines are abnormal. Methods : Patients were divided into two groups; Group 1 (migraine with aura; MWA, n=29) and Group 2 (migraine without aura ; MOA, n=32) according to the International Headache Society criteria. PRVEPs were performed in both groups and in healthy volunteers (n=62). PRVEPs were averaged in 100 responses for a total duration of 10 minutes after an initial 3 minutes during stimulation and were analysed in terms of latencies and peak to peak amplitudes of N1-P1 and P1-N2 peaks. Results : Amplitudes of PRVEPs in migraines showed significant increases compared to normal subjects (p<0.001), and amplitudes of PRVEPs in MWA showed significant increases compared to those in MOA (p<0.05). Conclusions : These results are explained by cortical hypoexcitability and hyper-responsiveness in migraine and by addi-tional cortical hyper-responsiveness (another hyper-responsiveness) in MWA compared to MOA. We suggest that sero-tonergic and noradrenergic hyperactivity could be responsible for cortical hypoexcitability and hyper-responsiveness in a migraine brain. Another hyper-responsiveness in MWA could also be thought of as some evidence for cortical neuronal abnormality in MWA in addition to serotonergic and noradrenergic hyperactivity in a migraine brain.
J Korean Neurol Assoc 19(3):239~244, 2001
Key Words : Evoked potential, Migraine, Cortical response"
Keywords :
- 초록
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