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J Korean Neurol Assoc. 1999;17(5):702-704.
- Kleine-Levin Syndrome : Two Cases
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Soon Keum Lee, M.D., Sang-Ahm Lee, M.D.
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Department of Neurology, Asan Medical Center, College of Medicine, University of Ulsan
- Kleine-Levin 증후군 :2예
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이순금, 이상암
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울산대학교 의과대학 서울중앙병원 신경과
- Abstract
- Kleine-Levin syndrome (KLS) is characterized by recurring episodes of hypersomnia, megaphagia, and abnormal
behavior. We report two cases of KLS. Two boys, aged 18 (case 1) and 17 (case 2), had recurrent episodes of hyper-somnolence
with compulsive eating or drinking and hypersexuality for several years. HLA-DR typing was HLA-DR3
and 13 in case 1 and HLA-DR4 and 10 in case 2. Case 1 showed hypersomnia with early onset of REM sleep on MSLT
and frequent frontal intermittent rhythmic delta activity on EEG. Both cases showed no abnormalities on brain MRI.
HLA-DR typing facilitates differentiation between KLS and narcolepsy by the absence of HLA-DR2.
J Kor Neurol Ass 17(5):702~704, 1999
Key Words : Kleine-Levin syndrome, HLA-DR typing, MSLT
Keywords :
- 초록
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