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J Korean Neurol Assoc. 1999;17(5):694-701.
- Effect of Physical Exercise on Experimental
Steroid-Induced Myopathy
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Sang-Jun Park, M.D., Min-Chul Lee, M.D.*, Sei-Jong Kim, M.D.
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Department of Neurology and Pathology*, Chonnam National University Medical School
and Research Institute of Medical Sciences
- 운동이 백서 스테로이드 근병증에 미치는 효과
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박상준, 이민철*김세종
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전남대학교 의과대학 신경과학교실 ·병리학교실*·의과학연구소
- Abstract
- Background
: Steroid myopathy is an unexpected side effect to the prolonged therapeutic use of steroids. To treat
steroid myopathy, the followings are recommended; reduction of the steroid dose, usage of a nonfluorinated steroid,
and conversion to an alternate day regimen. As muscle loading is encouraged in maintaining normal muscle properties,
it is also apparent that physical exercise may be useful in the prevention and treatment of steroid myopathy. Methods :
The experiment was designed to investigate the effects of exercise on steroid myopathy. Rats being treated with triam-cinolone
acetonide (TA) (5 mg/kg/day) for 7 days exercised on a treadmill (speed 20m/min, 30 min/day, 3 days/week)
for 2 weeks. The extensor digitorum longus (EDL) and soleus were then examined histochemically and ultrastructural-ly.
Results
: Rats treated with TA showed significant loss of body and muscle weight. In the TA treated group, cross-sectional
areas of type II fibers of both EDL and soleus were decreased in comparison with the controls. Necrotic
changes were found only in type II fibers of the soleus. Recovery from the weight loss with type II fiber atrophy was
more pronounced in the exercise group than that of the sedentary group, but was not significant statistically.
Ultrastructural abnormalities, that consisted of subsarcolemmal mitochondrial accumulation, mitochondrial vacuolation,
increased number of mitochondria in autophagic vacuoles, and dilatation of sarcoplasmic reticulum, were seen in TA
treated muscles. These injuries were significantly reduced by the exercise, however, complete recovery could not be
seen. Conclusions : These results suggest that treadmill exercise for 2 weeks partially ameliorate steroid myopathy in
J Kor Neurol Ass 17(5):694~701, 1999
Key Words : Steroid Myopathy, Exercise, Steroid, Histological Findings
Keywords :
- 초록
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