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J Korean Neurol Assoc. 1999;17(3):394-402.
- Expression of Vascular Endothelial Growth Factor and Its Relation with Neovascularization and Apoptosis in Grading of Astrocytic Tumors
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Doo-Cheon Kim ? Min-Cheol Lee* ? Sei-Jong Kim
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Department of Neurology, Pathology*,
Chonnam University Medical School
and Research Institute of Medical sciences
- 성상세포종양에서 VEGF발현과 혈관신생 및
세포자멸사와의 상관성
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김두천, 이민철*, 김세종
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전남대학교 의과대학 신경과학교실, 병리학교실*, 의과학연구소
- Abstract
- Background
The vascular endothelial growth factor (VEGF) is known as a potent mediator of brain tumor angio-genesis,
vascular permeablity, and glioma growth. This study was designed to study the balance between growth and
death signals in different grades of astrocytic tumors. Methods: Using immunohistochemistry, the relationship between
the expression of VEGF and microvessel count and density were evaluated in 62 cases of astrocytic tumors including
33 low grade astrocytomas, 6 anaplastic astrocytomas, and 23 glioblastomas. In order to determine the apoptotic index
(AI), the in situ end-labeling method was applied. Results: VEGF was expressed on the tumor cell cytoplasm. Of 62
tumors, 44 (77%) were weak to strong postive for VEGF, but 18 cases were not reactive. VEGF positivity was correlat-ed
with WHO grades of the astrocytic tumors; low grade astrocytomas (52%), anaplastic astrocytomas (83%), and
glioblastomas (96%). Mean microvessel count and density were significantly higher in VEGF-positive tumors (75.7
and 4.1%) than in VEGF-negative tumors (43.9 and 2.5%). Apoptotic cells were readily found in the astrocytic tumors;
the highest value of AI was observed in glioblastomas (8.6%) and the lowest in anaplastic astrocytomas (1.9%). It
seemed that the grade of malignancy was not related with AI values. Conclusions: These results suggest that VEGF
promotes angiogenesis with tumor cell growth against apoptotic cell death in the human astrocytomas.
J Kor Neurol Ass 17(3):394 ~ 402, 1999
Key Words : VEGF, Apoptosis, Neovascularization, Astrocytoma, Grade
Keywords :
- 초록
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