-
-
J Korean Neurol Assoc. 1999;17(3):365-369.
- The prognostic factors of seizure recurrence in newly diagnosed epilepsy
-
Dong-Seon Kim M.D., Sung-Eun Kim M.D., Jeong-Ho Kim M.D.*, Kyeung Heo M.D.**
Department of Neurology, Department of Preventive Medicine*, Inje University, Pusan Paik Hospital, Department of Neurology, Bundang Cha Hospital**
-
Department of Neurology
Pusan Paik Hospital, Inje University
- 새롭게 진단된 간질 환자에 있어서 발작의 재발에 대한 예후적 인자
-
김동선, 김성은 김정호* 허경*
-
인제대학교 의과대학 신경과학교실, 예방의학교실*, 분당 차병원 신경과학교실
- Abstract
- Background
To evaluate the prognostic factors of seizure recurrence in newly diagnosed epilepsy at 1 year follow
up. Methods: From the IUED (Inje University Epilepsy Database) we retrieved the epilepsy patients who had never
before taken any antiepileptics (AED) and were followed up for 1 year. We retrospectively reviewed the medical
records with special attention to : a) age of onset, b) history of antecedents, c) seizure frequency before starting AED,
d) abnormal neurological examination, e) MRI findings, f) EEG findings, g) epileptic syndrome classification. We
defined seizure recurrence as any seizure occurring during the 1 year evaluation follow up except during the AED titra-tion
period, having only an aura and being in poor compliance. We analyzed the prognostic factors that could reliably
predict the seizure recurrence at 1 year follow up. Results: We found 104 patients (64 male, 40 female) who met the
inclusion criteria. The mean age of onset was 23.7 years. Of 104 patients 19 had generalized epilepsy, 82 had partial
epilepsy and 3 had unclassified epilepsy. Thirteen percent (13/104) developed seizure recurrence at the 1 year follow
up. Significant univariate associations were noted between seizure recurrence and these factors: presence of
antecedents 〔odds ratio (OR) 4.8; 95% confidence interval (CI) 1.2-18.5 〕, post-encephalitic epilepsy (OR 7.7; 95% CI
2.1 ~ 28), and abnormal neurological examination(OR 14.6; 95% CI 3.9-55). With multivariate logistic regression, the
independent predictor of seizure recurrence was the abnormal neurological examination (OR 9.7; 95% CI 2.4 ~ 39.4).
Conclusions
The chance of developing a seizure recurrence at the 1 year follow up was 13 percent and the prognostic
factors were the presence of antecedents, post-encephalitic epilepsy and an abnormal neurological examination.
J Kor Neurol Ass 17(3):365 ~ 369, 1999
Key Words : Prognostic factor, Seizure recurrence, Antecedents, Post-encephalitic epilepsy,Abnormal neurological examination
Keywords :
- 초록
-
