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J Korean Neurol Assoc. 1996;14(4):1067-1071.
- Herper Zoster Myelitis Confirmed by Detection of Varicell-zoster Virus DNA Using the Polymerase Chain Reaction
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Moon Ku Han, M.D., Sang Soo Lee, M.D., Seol Heul Han, M.D.
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Department of Neurology, College of Medicine, Chungbuk National University
- 중합효소연쇄반응을 이용한 varicella-zoster virus DNA의 검출로 확인된 대상포진 척수염
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한문구, 이상수 한설희
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충북대학교 의과대학 신경과학교실
- Abstract
- We report a case of progressive myelopathy following herpes zoster skin eruption In adult. Varicella-zoster virus (VZV) myelopathy was diagnosed based on the close temporal relationship between rash and onset of myelopathy, and confirmed by demonstrating the presence of varicella-zoster virus DNA in the cerebral spinal fluid (CSF) by amplification using the polymerase chain reaction (PCR) . The patient was treated with intravenous acyclovir, and strength, sensation, sphincter function improved within 2 weeks. Detection of VZV DNA in CSF was useful for diagnosis and a role of virus In the pathogenesis of myelopathy. The clinical Improvement suggests that early therapy with an effective antiviral drug was beneficial.
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