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J Korean Neurol Assoc. 1995;13(2):291-297.
- TNFa and Bacterial Meningitis
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YB Choi, M.D., JH Park, M.D., JH Rha, M.D., YI Kim, M.D., Ks Lee, M.D., BS Kim, M.D.
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Department of Neurology, Catholic University Medical College
- 뇌척수액 종양괴사인자 (Tumor necrosis factor a) 와 세균성 수막염
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최영빈, 박지현, 나정호, 김영인, 이광수, 김범생
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가톨릭대학교 신경과
- Abstract
- Objective/Background : We evaluate the role of TNFa in the generation of inflammation and the blood-brain barrier damage in the patients with bacterial and aseptic meningitis.
Methods
: We recruited three groups for analysis - (1) bacterial meningitis (6pati ents)
(2) aseptic meningitis (7patients) (3) non-infectious neurologic disease (7patients). CSF
and serum were studied for WBC, albumin concentration and TNFa assay by cytolytic
method.
Results
: TNFa of CSF, and albumin quotient (Qalb: degree of blood-brain barrier
damage) in bacterial meningitis groups were significantly higher than those in control
groups(TNFa : 163.23+58.17units/ml, p<0.05 & Qalb : 13.75+5.16, p<0.05). TNF ratio(CSF
TNF/SerumTNF) was well correlated with albumin quotient(p<0.05, r=O. 96).
Conclusions
We conclude that TNFa level is higher in bacterial meningitis group than
in other groups. TNFa may play a important role in the pathogenetic process of
bacterial meningitis, especially in the destruction of blood-brain barrier.
Keywords :
- 초록
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