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J Korean Neurol Assoc. 1995;13(1):47-53.
- Study on Clinical Courses of Vasculitic Neuropathies
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Gyeong Moon Kim, M.D., Dae Won Seo, M.D., Sang Bok Lee, M.D., Ho Jin Myung, M.D., Kwang Woo Lee, M.D.
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Department of Neurology, College of Medicine, Seoul National University
- 혈관염증성 말초신경병증의 치료경과에 관한 연구
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김경문, 서대원, 이상복, 명호진, 이광우
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서울대학교 신경과
- Abstract
- Vasculitic neuropathy is a clinical manifestation affecting peripheral nerve in necrotizing vasculitis. It is generally regarded that natural courses are poor as there are abundant histologic and electrophysiologic evidences of axonal destruction. In this study, authors collected 15 cases of vasculitic neuropathy these six years and analyzed the data retrospectively to understand the clinical course.
In 15 cases, the diagnosis of vasculitic neuropathy was made by the prominent clinical
features, electrophysiological findings and sural nerve biopsies. Four cases were
associated with polyarterits nodosa, one with systemic lupus erythematosus, two with
rheumatoid arthritis, and one with polyangiitis overlap syndrome. However in other
seven- cases the underlying dignoses were not made completely, but suspected some
vasculitic conditions, such as isolated PNS vasculitis or undefined connective tissue
disease. Electrophysiological studies showed mononeuritis multiplex in six, sensonmotor
polvneuropathy in seven, and overlapped mononeuritis multiplex and polyneuropathy in
two. Typical necrotizing vasculitis was found in nine out of twelve sural nerve
biopsies.
During the follow up period for up to two years, there was much improvement in ten,
slight in three, and no improvement in two. In ten out of twelve patients prednisolone
or prednisolone plus cyclophosphamide regimens showed improvement.
Therefore authors thought that the clinical outcome was relatively fair in vasculitic neu .
Ropathy when the therapy was started very early and the tirne factor between the onset
and the uutiation of immunosuppressant therapy could be very important and critical.
Keywords :
- 초록
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