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J Korean Neurol Assoc. 1994;12(3):375-381.
- Development and Persistence of Kindling Phenomenon after ?Injections of Pentylenetetrazol in Rats
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Seung Hwan Lee, M.D., Sang Doe Yi, M.D., Young Choon Park, M.D.
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Department of Neurology, Keimyung University School of Medicine
- 백서에서 Pentylenetetrazol 주사후 Kindling의 발달 단계 및 지속성
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이승환, 이상도,박영춘
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계명대학교 신경과.
- Abstract
- The development of pentylenetetrazol (PTZ) kindling has been controversial, authors confirmed the development of kindling phenomenon in experimental rats following every second or third day intraperitoneal administration of PTZ(20-25mg/kg) to experimental rats and same amount of saline to control rats. The developmental stage of motor seizure could be categorized into five stages (stage I ; clonic seizure of face and neck, stage II ; clonic seizure of face, neck and forelimbs, stage III ; clonic seizure of forelimbs and body with brief rearing, stage IV ; falling and generalized clonic seizure, stage V ; falling and generalized tonic-clonic seizure with tonic extension of hindlimbs). Linear regression analysis showed that the stages of motor seizure were increased with the number of PTZ injections (Y=0.1361X + 0.1943, p < 0.05). The persistence of kindling state was also observed after a 5-months pause of PTZ injection.
This study suggested that PTZ kindling model in rats could be a good animal model of
generalized epilepsy.
Keywords :
- 초록
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