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J Korean Neurol Assoc. 1992;10(4):420-427.
- Quantitative Change of Repetitive Nerve StimulationTest in Myasthenia Gravis
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Ki-Han Kwon, M.D., Sang-Am Lee, M.D., Il-Nam Sunwoo, M.D.
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Department of Neurology, Seoul Christian Hospital, Department of Neurology, College of Medicine, Ulsan University, Department of Neurology, College of Medicine, Yoensei University
- 중증 근무력증에서 나타난 반복신경자극검사의 정량적 변화
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권기한, 이상암,선우일남
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서울기독병원 신경과. 울산대학교 신경과. 연세대학교 신경과.
- Abstract
- Repetitive nerve stimulation test (RNS) is an easy and non-invasive test which provides objective for the presence of a myasthenic neuromuscular defect and for monitoring possible improvement through various therapeutic measures, and makes the differentiation of neuromuscular junction disorders. Analysing the RNS test of 45 normal controls and 146 patients with myasthenia gravis quantitatively, the following results obtained. 1. At low rate stimulation, the decremental response upto 2 standard deviation in normal control are 7.1% in orbicularis oculi(~), 7.6% in flexor carpi ulnaris (FCU) and
5.4% in abductor digiti guinti muscle(ADQ). There are two kinds of facilitation noticed:
incremental responses at repetitive low stimulation (13.3-14.9%) immediately after tetanic
stimulationy and increased mean amplitudes of compound muscle action potentials after
exercise(l3-17%). Four minutes after the tetanic stimulation, the decremental responses
at low rate stimulation become accentuated slightly even in normal control group. 2. At
low rate stimulation. There are singificant decremental decremental responses in patients
with myasthenia gravis, but statistically no significant differences are seen in the
quantity of decremental responses among 2, 3 and 5/sec rate of stimulation. 3. The
pattern and severity of decremental responses at low rate stimulation are depending on
the clinical type of generalized myasthenia gravis. There are no decremental responses
in FCU or ADQ in ocular type. The decremental responses of oo are greater than that
of FCU in mild generalized myasthenia, but the reverse is true in moderate generalized
type. 4. Statistically significant post-tetanic facilitation and exhaustion are noticed in
patients with generalized myasthenia gravis.
Keywords :
- 초록
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