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J Korean Neurol Assoc. 1992;10(3):308-315.
- Effects of Central Dopaminergic Receptor-Activation on the Cardiovascular System
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Seung-Min Kim, M.D., Young-Kwan Park, M.D., Sung-Soo Lee, M.D., Chang-Mann Ko, M.D.
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Department of Neurology and Pharmacology, College of Medicine, Yoensei University
- 중추 Dopamine성 수용체흥분이 심혈관계에 미치는 영향
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김승민, 박영관,이성수,고창만
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연세대학교 신경과, 약리학.
- Abstract
- The central dopaminergic receptor is believed to suppress the cardiovascular system So it may be involved in the blood pressure regulation But, it's action is still controversial. Furthermore, the mechanisms involved in the central dopaminergic receptor-induced blood pressure regulation is unclear. So, present study was performed in order to clarify the effects of central dopaminergic receptor and to investigate the mechamisms involved in it. Lisuride a D2-receptor agonist, and clonidine, a alpha2-receptor agonist, were administered into lateral ventricle in rat and the changes of blood pressure were compared The results were as follows;
1. Intracerebroventricular administration of lisuride amd clonidine from 0.3 ug to 10 ug
elicited dose related decrease of blood pressure and heart rate. The potencies were
similar in both drugs. 2. Centrally administered sulpiride, a D2-antagonist, blocked only
the lisuride-induced hypotension while the clonidine induced hypotension was blocked
only by centrally adrninistered tolazoline, a alpha2-antagonist. Intravenous administration
of both antagonists elicited no or minimal attenuabon of agonists effects. 3. After
desipramine pretreatment, which increases the norepinephrine concentration lisuride
elicited somewhat further decrease of blood pressure than normal, while clonidine
administration caused rather increase in blood pressure. 4. After chemical
sympathectomy by 6-hydroxydopamine, lisuride administration still elicited strong
suppression of blood pressure.
From thses above results, it is concluded that central dopaminergic receptor activation
decrease the blood pressure. Suppression of the norepinephrine release at the
sympathetic nerve terminal is not related with central dopaminergic receptor induced
hypotension.
Keywords :
- 초록
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