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J Korean Neurol Assoc. 1991;9(4):413-417.
- Effect of Nimodipine on Ischemic Brain Edema of Gerbil
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Il Keon Lee, M.D., Byung Woo Yoon, M.D., Jae Kyu Rho, M.D.
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Dep. Of Neurology, Seoul National University
- Gerbil의 허혈성 뇌부종에 대한 Nimodipine의 효과
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이일근, 윤병우,노재규
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서울대학교 신경과
- Abstract
- The mechanisms involved in brain neuronal damage in ischemia are related to the elevation of cytosolic calcium concentration and calcium antagonist is considered as a promising drug that may alleviate ischemic neuronal damage. Using transient global ischemia model of Mongolian gerbil, we studied the effect of nimodipine, a cerebroselective calcium antagonist, on ischemic brain edema. We treated each gerbil intraperitoneally with nimodipine (lmg/kg) or the same amount of saline 30 minutes prior to ischemia, and transient global ischemia was induced by means of clipping both common carotid arteries either for 10 minutes or for 45 minutes. Three hours after reperfusion, the animals were decapitated and the water content of the bain was determined by oven dry method. With 10 minute ischemia the brain water content in nimodipine pretreatment group (?8.6+0.2%) was lower than that in saline pretreatment
group (79.1+ 0.4%) significantly (p< 0.05). But with 45 minute ischemia nimodipine
pretreatment did not reduce the postischemic increase of water content compared with
saline pretreatment (79.8 0.4% and 79 6 + 0.4%, respectively; not significant). Our
results
suggest that nimodipine pretreatment may suppress the development of ischemic
brain edema and its effect depends largely on the extent of brain ischemia.
Keywords :
- 초록
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