- J Korean Neurol Assoc. 1991;9(3):341-348.
- Injection Sites and Doses in the Treatment of Cervical Dystonia with Botulinum A Toxin:A Preliminary Report
- Bong Ae Wie, M.D., Kwang Woo Lee, M.D., Jae Kyu Roh, M.D., Sang Bok Lee, M.D., Ho Jin Myung, M.D.
- Dep. Of Neurology, Seoul National University
- 경부 Dystonia 치료에서 보튤리눔 A독소 주사 위치 및 용량에 대한 예비적 조사
- 위봉애, 이광우,노재규,이상복,명호진
- 서울대학교 신경과.
- Abstract
- We administered local injections of botulinum A toxin to 15 patients wlth medically intratrable cervical dystonia Thirteen of the patients (87%) improved substantially (global effect>3 ; fiom -l = aggravated to +5 = markedly improved, fully functional, very happy with the results), with a mean total dose of 75.9 units. Of the 8 patients who reported pain, 7 (88%) had almost complete re!ief of pain. Only 6 of 15 (40%) patients had mild to moderate complications. More muscles had been injected in rotatocollis (mean, 5.2) than in laterocollis (mean, 3.0) (p<0.05). The global effects in rotatocollis (mean, 3.4) and laterocollis (mean, 3.3) were significantly better than anterocollis (mean, 1.5) (p<0.05). We conclude that botulinum A toxin is also effective in low doses when given in due consideration of the cervical muscle contraction patterns.
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