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J Korean Neurol Assoc. 1990;8(2):249-255.
- The Effect of Carbon Monoxide Intoxication on The Metabolites of Monoamine Neurotransmitters in Human Cerbrospinal Fluid
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Dong Kwon Kim, M.D., Hong Ki Song, M.D., Ju Han Kim, M.D., Kyung Cheon Chung, M.D. Yong Sung Lee, M.D.*
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Department of Neurology & Biochemistry* , College of Medicine, Hanyang University
- 일산화탄소중독이 뇌척수액 신경전달물질의 대사물질에 미치는 영향
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김동권, 송홍기, 김주한, 정경천, 이용성
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한양대학교 신경과, 생화학.
- Abstract
- This study was done in order to show the effects of carbon rnonoxide (CO) induced hypoxia on the steps of metabolism of rnonoamine neurotransmitters. There were 9 patients exposed to CO and 5 patients of control group. We evaluated their cerebrospinal fluid within 24 hours after CO exposure. And we measured the amounts of 5-hydroxy-indole acetic acid (5-HIAA) and homovanillic acid (HVA) with high performance liquid chromatography (HPLC). In the CO exposure group, the levels of 5-HIAA and HVA were reduced compared with the control group. It was thought that the changes in the levels of 5-HIAA and HVA were due to the transient decrease in monoamine oxidase activity in acute hypoxia.
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- 초록
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