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J Korean Neurol Assoc. 1989;7(2):295-307.
- Correlation of Cognitive Evoked Potentials with Memory Tests in Patients with Memory Disturbance
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Namsoo Lee, M.D., Kwang Woo Lee, M.D., Jae Kyu Roh, M.D., Sang Bok Lee, M.D., and Hojin Myung, M.D.
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Department of Neurology, College of Medicine, Seoul National University
- 기억력저하 환자에서의 인식유발전위와 기억력 검사의 상관관계에 관한 연구
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이남수, 이광우 , 노재규, 이상복, 명호진
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서울대학교 신경과.
- Abstract
- We performed 3 kinds of memory tests and cognitive evoked potential study, P300, in 13 patients with memory disturbance and 19 control free of neurologic symptoms or history of neurological impairment; to determine correlation of each memory test with P300 and possibility of clinical application of P300 as a quantitative test of cognitive function.
Patients and control younger than 40 years of age were selected to minimize the
aging effect on the cognitive function tests. Those who marked 30 points in
Mini-mental state examination were chosen as control. 11 of 13 patients had brrain
lesions including temporal lobe.
Comparing with tests in control group, the declarative ant the procedural memory
of patients were significantly impaired (p<0.05, p<0.025, respectively), and P300 latency
was significantly prolonged (p<0.001). In control group, among declarative memory tests
Rey-Osterreith complex figure test and enhanced cued recall had significant correlation
with P300 latency (p<0.05, p<0.05, respectively), while the Tower of Toronto test which
was known to evaluate precedural memory did not. In patient group there was no
significant correlation between any kind of memory test and P300 latency.
These results not only are consistent with previous studies which detected
temporal lobe as the origin of P300 wave, but implicate that brain loci other than
temporal lobe might originate P300 wave. To apply P300 as a quantitative test of
cognitive function, further extensive studies using age and IQ matched control will be
needed.
Keywords :
- 초록
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