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J Korean Neurol Assoc. 1989;7(1):165-171.
- Two Cases of Reversible Leukoencephalopathy, Caused by 5-Fluorouracil, Presenting as Akinetic Mutism
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Se-Jin Lee,M.D., Kyung-Chan Choi,M.D., Jung-Sang hah,M.D., Yeung-Ju Byun,M.D., Choong-Seo park,M.D.
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Department of neurology , College of medicine, YoungNam University Department of neurology , College of medicine, Keimyung University
- 5-FU 제제로 인하여 무동성 무언증을 보인 가역적 백질뇌병증 2예
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이세진, 최경찬,하정상,변영주,박충서,이상도,박영춘
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영남대학교 신경과. 계명대학교 신경과.
- Abstract
- We experinced 2 cases of reversible leukoencephalopathy, caused by 5-Fluorouracil
derivatives(carmoful), presenting as akinetic mutism. Each patient was diagnosed as colon cancer and
stomach cancer respectively and received operations. Their outcome was good without metastatic
evidences, and carmoful was started orally 400mg in 1 case and 600mg in the other. Their clinical
pictures were akinetic mutism, one and two months after the administration of carmoful. There were no
metastatic lesions in the brain CT but bilaterally symmetric diffuse low densities of cerebral whites
matter, predominantly in the frontal area, were noted. Carmoful was discontinued and replaced by
conservative treatment.
One and two months later, their clinical symptoms improved without specific treatment. Follow up
brain CT was done in case 2, which revealed attenuation of the previous low densities.
Keywords :
- 초록
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