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J Korean Neurol Assoc. 1989;7(1):26-34.
- Flash ERG changes in Parkinson's disease
-With reference to medications and clinical forms-
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Jae-Moon Kim,M.D., Seol-Hee Han,M.D., Kwang-Woo Lee,M.D., Sang-Bok Lee, M.D., Ho-Jin Myung,M.D.
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Department of neurology , College of medicine, Seoul National University
- 파킨슨씨 병에서의 Flash ERG의 변화에 대하여
-투약과 임상증세에 따른 변화를 중점으로-
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김재문, 한설희,이광우,이상복,명호진
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서울대학교 신경과.
- Abstract
- Authors have studied photopic and scotopic flash EPGs for 19 control subjects and 20 patients with
Parkinson's disease before and after various anti-Parkinsonian therapy. The following fingings were
observed
1. There was no significant difference in implicit time of photopic and scotopic a and b waves
between the control and the Parkinsonian groups(P(t)>0.05).
2 Amplitudes of photopic and scotopic a and b-waves were smaller in Parkinsonian group during the
pre-medication therapy than in control group(P(t)<0.05) however those of photopic a-and b- waves and
scotopic b-wave were normalized with anti-Parkinsonian therapy(P(t)<0.01).
3 Parkinsonian patients treated with dopa preparations showed the significant increases of amplitde of
scotopic b wave(P(t)<0.001) but those treated with anticholinergics, Amantadine or Bromocryptine did
not(P(t1>0.05).
4. Compared with that of tremor predominant Parkinsonism the amplitudes of photopic and scotopic
a-and b-waves were small in patients with akineto-rigidity(P(t)<0.01).
Therefore it is concluded that the dopaminergic changes in retinal cells are responsible for producing b
wave as well as a wave. So clinically flash EFGs can. Be used beneficially in treating Parkinsonian
patients in view of choosing the anti-Parkinsonian drugs and monitoring the effectiveness of therapy
Keywords :
- 초록
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