-
-
J Korean Neurol Assoc. 1989;7(1):19-25.
- The Therapeutic Effect of Drug in Parkinson's Disease
-
Il-Saing Choi,M.D., Myung-Sik Lee,M.D., Young-Jin Lee,M.D., Won-Young Chung,M.D., Sung-Soo Lee,M.D., Won-Tsen Kim,M.D.
-
Department of neurology, Yong Dong Severance Hospital, College of Medicine, Yonsei University
- 파킨슨병에 있어서 약물치료 효과
-
최일생, 이명식,이영진,정원영,이성수,김원천
-
연세대학교 신경과.
- Abstract
- Two hundred and four patients with Parkinson's disease initially treated wth a combination of levodopa
and carbidopa ( Sinement 25-250 ) and / or anticholinergic drugs.
All patients responded initially to drug. Sixteen patients(7.8%) had 20 acute central nervous system
side effects: 8, dyskinesia: 6, visual hallucination:5, psychosis: and 1, akathisia.
The response to treatment usually was stable for the first one and a half to four years of drug therapy.
Subsequently, over 50 percent of patients had therapeutic failure among 82 patients with long term drug
therapy, fourteen(l7.0%) had 18 side effects: 8, on-off phenomenon: 4. Morning dystonia: 3,
dyskinesia:and 3, simultaneous dyskinesia with parkinsonism. None had diphasic dyskinesia or
myoclonus.
The prognosis of the demented parkinsonian was relatively poor. Two patients died due to pneumonia
and ovarian carcinoma.
Keywords :
- 초록
-
