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J Korean Neurol Assoc. 1985;3(1):10-16.
- Neurochemical Changes in Alzheimer's Disease
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Jin-Soo Kim, M.D.
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Department of Neurology, Yunse Universiry
- Alzheimer's disease의 신경화학적 변화에 관한 고찰
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연세대학교 신경과.
- Abstract
- The prevalence for the development of dementia is about 10% and 20% in people over the age of 65 and 80, respectively. Underlying causes for its development are various. With the progress of modem medicine, the mean survival age is dramatically increased and for the consequence, greater number of people suffer from dementia.
According to the postmortem studies, 70% of the dementia patients were of the
Alzheimer's type. In recent times, active research on the relationship between the Alzheimer's
disease and the neurochemical changes is being conducted and much progress has been made.
In addition to the consistant deficiency of cholinergic system, abnormal ities in noradrenergic
and GABAergic systems and reductions of somatostatin have been reported.
In the same areas of brain of patients who suffered from Alxheimer's disease where
these changes of neurotransmitters were found, there were massive accumulation of
aluminium.
Therefore, this review discusses the specific changes of various neurotransmitters in the
brain and the potential therapeutic agents in Alzheimer's disease.
Keywords :
- 초록
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