J Korean Neurol Assoc > Volume 29(3); 2011 > Article
Journal of the Korean Neurological Association 2011;29(3): 159-164.
대사증후군과 치매
충남대학교 의학전문대학원 신경과학교실
Metabolic Syndrome and Dementia
Ae Young Lee
Department of Neurology, Chungnam National University School of Medicine, Daejeon, Korea
Abstract
The essential components of metabolic syndrome are insulin resistance, obesity, hypertension, and dyslipidemia. It is difficult to estimate its prevalence because several definitions of metabolic syndrome are in use. Although the exact cause-effect relation between metabolic syndrome and dementia is still controversial, the incidence of dementia and Alzheimer disease is relatively higher in individuals with metabolic syndrome than in those without it, regardless of mechanism. The pathophysiology of hyperinsulinemia and insulin resistance is responsible for causing cognitive decline or dementia in the elderly people, and It seems to be attributable to cerebral hypoperfusion and excessive Aβ deposition in the brain by insulin. Therefore, therapeutic intervention by modulating Aβ deposition and cerebral perfusion might be helpful to prevent patients with metabolic syndrome from getting cognitive dysfunction or dementia. KeyWords:Metabolic syndrome, Dementia, Hyperinsulinemia, Insulin resistance


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