Follow-up Study of Brain MRI and Clinical Course in Patients with Wilson's Disease

J Korean Neurol Assoc > Volume 11(3); 1993 > Article

Journal of the Korean Neurological Association 1993;11(3): 341-347.

Wilson 병에서 동 (Cu) 제거치료 전후의 임상 및 뇌 자기공명영상(MRI)의 비교연구

이태규, 노재규,위봉애,박성호,장기현,이상복

서울대학교 신경과, 진단방사선과.

Follow-up Study of Brain MRI and Clinical Course in Patients with Wilson's Disease

T. G. Lee, M.D., J. K. Roh, M.D., B. A. Wie, M.D., S. H. Park, M.D., K. H. Chang, M.D., S. B. Lee, M.D.

Department of Neurology and Radiology, College of Medicine, Seoul National University

Abstract

We studied 16 patients with neurologically symptomatic Wilson's disease(WD) before and after D-penicillamine therapy by using brain MRI and functional disabi!ity score over the mean follow up penod of 12 months. The most common abnormal findings on pre-treatment MRIs were high signal intensity(HIS) lesions located in the thalami(100%) and brain atrophy( 100%). HIS lesions usually improved on the follow-up MRIs in accordance with the clinical improvement. HIS lesions in the thalami improved more rapidly and more extensively than those in the basal ganglia. Low signal intensity(LSI) lesions were located mostly in the basal ganglia. And did not show any proportional changes on the follow-up MRIs.