Factors Affecting Prognosis of Temporal Lobe Epilepsy

J Korean Neurol Assoc > Volume 18(5); 2000 > Article

Journal of the Korean Neurological Association 2000;18(5): 601-608.

측두엽간질의 예후에 영향을 미치는 인자

김옥준, 김장성*·이병인†

포천 중문 의과대학교 신경과학교실,아주대학교 의과대학 신경과학교실*,연세대학교 의과대학 신경과학교실†

Factors Affecting Prognosis of Temporal Lobe Epilepsy

Ok-Joon Kim, M.D., Jang-Sung Kim, M.D.*, Byung-In Lee, M.D.†

Department of Neurology, Pochon CHA University, College of Medicine Department of Neurology, Ajou University, College of Medicine* Department of Neurology, Yonsei University, College of Medicine†

Abstract

Background : Although the poor short-term outcome of antiepileptic drug (AED) treatment may represent long-term AED refractoriness in general, the same hypothesis in temporal lobe epilepsy (TLE) has yet to come up as an important subject to be investigated. We examined to decide early drug intractability and aid treatment plan. Methods : From a prospective patient cohort of Yonsei Epilepsy Clinic, 121 newly-referred TLE patients were selected to participate in this study. First, we divided the patients into two groups according to their second one-year remission at two year of AED treatment. One group was the remission group (RG) and the other was the non-remission group (NRG). Second, we evaluated clinical characteristics influencing remission between the two groups. Results : Nineteen patients (15.7%) were RG whereas 102 (84.3%) were NRG. The six month remission and terminal remission at the first year of AED treatment and the first one year remission rate in patients with RG was significantly higher than those with NRG (P<0.05). In patients with NRG, the number of complex partial seizures and secondary generalized seizures, the annual frequency of secondary generalized seizures prior to AED treatment, polypharmacy, new drug use, and drug side effects were significantly higher (p<0.05) than RG. Conclusions : The earlier seizure outcome may influence the later progno-sis of AED treatment in non-lesional TLE. The prognosis during the second year of AED treatment is influenced by drug treatment and the number of generalized seizures. J Korean Neurol Assoc 18(5):601~608, 2000 Key Words : Epilepsy/Temporal lobe, Anticonvulsants, Prognosis